THE BEST SIDE OF PKRRATING

The interfacial residues are hugely conserved amongst eIF2α kinases and mutagenesis implicates the BTB dimer in PKR function18. FRET measurements display the kinase domains dimerize when PKR binds to activating dsRNAs19. These observations assistance a product exactly where activating RNA serves as a scaffold to bind multiple PKR monomers, increas

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